The game also provides an open-world experience allowing you to explore the whole map for as long as your heart desires. The decisions you make also have a huge effect on the outcome of your game, making every choice count. They both offer similar inventory management, looting, crafting, and collecting gear. Fallout 4 is widely considered as one of the best Fallout games because of its challenging gameplay, good storyline, and excellent graphics.įallout 4 has a ton of mechanics that are just like Outer Worlds. It’s set in the year 2287 and has you exploring a post-apocalyptic America that looks like a shell of the past. Fallout 4 is an award-winning game from Bethesda. If you enjoyed the story of the Outer World and liked playing some of the Telltale games, Beyond a Steel Sky is the game for you.īeyond a Steel Sky was released in June 2020 and is available on PlayStation, Xbox, PC, and iOS. It’s a modern story game that involves no combat elements. It features some challenging puzzles, a choice-based narrative, and amazing comic book-like graphics that are perfect for the genre. However, a few nods and references will be made to Beneath a Steel Sky.īeyond a Steel sky is a 3D point-and-click adventure game that focuses on telling a story. You can fully enjoy Beyond a Steel Sky without knowing anything about the first game. You don’t need to play the original game to understand the complete story. It’s set ten years after the original game, and you play as Robert Foster in a utopian city called Union City. Beyond a Steel Skyīeyond a Steel Sky is actually a sequel to the 1994 cyberpunk sci-fi game, Beneath a Steel Sky. Grounded was released in July 2020 and is available on Xbox and PC. Easily making it one of the best online multiplayer games for Xbox, especially if you’re into base-building.Īnd while Grounded isn’t exactly a game like the Outer Worlds, it can still scratch that exploration and RPG itch while providing a stunningly unique experience. You can also play co-op with up to 3 other players. Build a base, cook food, craft weapons, equip armor, and manage your perks to help you survive the harsh nature of your backyard. The game also allows you to completely explore the backyard and discover how you can turn back into a regular-sized human. It also puts you in a rough position where you have to battle ants, spiders, beetles, and other creepy crawlies. Grounded allows you to collect resources and build a base using items within your backyard. Even something as simple as swimming in the pond can feel like you’re on a completely different planet. The backyard doesn’t exactly scream “Outer Worlds,” but your new size gives you a whole new perspective of your backyard. In Grounded, you play as a character who has mysteriously transformed into the size of an ant. Have you ever imagined what the world would look like if you got shrunken down? Well, look no further than Grounded. Borderlands 3 was released in September 2019 and is available on PlayStation, Xbox, and PC. Luckily, you don’t have to play the other games to understand the mechanics and story of the game. You also get to encounter various out-of-this-world enemies that will surely get you feeling like the Outer Worlds all over again.īorderlands 3 is already the 4 th game in the franchise. If you were an item hoarder in The Outer Worlds, you’d love Borderlands 3 even more.īorderlands 3 is also set in a vast interconnected explorable area that allows you to get an open-world feeling. You’ll also continuously upgrade your weapons, find new loot, and pick up everything you see. Like The Outer Worlds, you’ll constantly manage your inventory in Borderlands 3. I know that The Outer Worlds isn’t exactly a shooter-looter game, but it does have some elements that Borderlands 3 excels at. Now, I know you might be wondering, “Isn’t Borderlands 3 a shooter-looter game?” – well, yes, it is.
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Medical workers have confirmed that multiple rounds of phage administration have a significant curative effect on refractory urinary tract infections triggered by MDR K. Not only that, phage therapy has also been applied in clinical practice. Studies based on mice as animal models have shown that phages have good therapeutic effects on pneumonia ( Anand et al., 2020), liver abscess ( Lin et al., 2014), burn infection ( Chadha et al., 2017), and bacteremia ( Kaabi and Musafer, 2019) caused by K. pneumoniae and have made some achievements. Until now, phage therapy have already been developed in various bacterial species including MDR K. Recently, due to the global emergence of multidrug-resistant bacteria, phage therapy has been experiencing a renaissance for its ability to combat their antibiotic-resistant host specifically. However, the development of this therapy has been hampered by the widespread use of antibiotics ( Nobrega et al., 2015). Owing to their specific bactericidal abilities, phages have been considered as therapeutic agents since the early 1920s. This massive phage diversity has a marked effect on the environment, ecology, and bacterial evolution ( Davies et al., 2016). It has been reported that there are more than 10 31 phage particles in the biosphere. In addition, the recent emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) has further exacerbated the dilemma of antibiotic treatment, provoking the need for alternative therapies ( Gu et al., 2018).īacteriophages (phages) are bacterial viruses that specifically recognize, infect, and replicate inside a host bacterium. pneumoniae, such as extended-spectrum β-lactamase (ESBL)-producing and carbapenemase -producing strains ( Navon-Venezia et al., 2017). What’s more, the existing antibiotics have failed to cure clinical infections caused by multidrug-resistant (MDR) K. The presence of at least 79 serotypes greatly increases the complexity of treatment for these bacterial infections ( Hsu et al., 2013 Pan et al., 2015). pneumoniae) causes fatal systemic infections ( Paczosa and Mecsas, 2016). Therefore, this study not only introduces a new member to the phage therapeutic library, but also serves as a reference for other phage-antibiotic combinations to combat MDR pathogens.Īs the second-ranked nosocomial infection-causing-pathogens, Klebsiella pneumoniae ( K. Furthermore, the combined treatment of P-KP2 and gentamicin completely rescued the infected mice. Besides, P-KP2 was comparable to gentamicin in the treatment of lethal pneumonia caused by K. The genome of P-KP2 shows homology with nine phages which belong to “ KP15 virus” family and its genome comprises 172,138 bp and 264 ORFs. P-KP2 presents high lysis efficiency in vitro. The biological characteristics of P-KP2 and the bioinformatics of its genome were analyzed, and then the therapeutic effect of P-KP2 was tested by animal experiments. pneumoniae was isolated and named as vB_KpnM_P-KP2 (abbreviated as P-KP2). In this study, a novel bacteriophage that specifically infects K. pneumoniae (CR-hvKP) has brought more severe challenge to the treatment of K. pneumoniae and carbapenem-resistant hypervirulent K. The emergence of multi-drug resistant (MDR) K. pneumoniae) is an important nosocomial and community acquired opportunistic pathogen which causes various infections. 5Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, China.4Department of Chinese Journal of Veterinary Science, Jilin University, Changchun, China.3Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun, China.2College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.1Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.Zijing Wang 1†, Ruopeng Cai 2†, Gang Wang 1†, Zhimin Guo 3†, Xiao Liu 1, Yuan Guan 1, Yalu Ji 1, Hao Zhang 1, Hengyu Xi 1, Rihong Zhao 1, Lanting Bi 1, Shanshan Liu 4, Li Yang 1, Xin Feng 1, Changjiang Sun 1, Liancheng Lei 1, Wenyu Han 1,5 and Jingmin Gu 1,5* You can search for information about Amazon and the Chimp tag, as well as IMDB and Yahoo stickers. Most of Windows is a Windows movie tagging program for MP4, M4V, and MOV files. The full version of the MetaX Key features an intuitive and easy-to-use interface. Download Metax Cracked Full Software Download In addition to that, it is also possible to edit all information and upload a custom image from your PC as long as the document format. Check boxes, then also write to each of the checklist files in the queue. The most important window will be divided into several sensitive panels that will allow you to quickly restart searches in several different locations, evaluate video information, form options, chapters, as well as display lists of numbers. MetaX Serial Number provides a user-friendly and easy-to-use interface. In addition to that, you can also manually edit the information and upload a custom image from the computer system as long as the file format is GIF, PNG, JPG, TBN, etc. You can also split, merge, or delete chapters. MetaX also lets you add labels for names, artists, programs, and album and album artists. MetaX allows you to copy tags from one file to another, open or close checkboxes, and write to all files in the queue. The main window is divided into several smart panels that allow you to quickly search multiple websites, check video information, filter options, chapters, and view queues. The full version of MetaX keygen has an easy-to-use and easy-to-use interface. You can also download Easy Disk Catalog Maker with Keygen. MetaX also allows you to disable AutoArchive mode, view movie ratings for specific countries, and delete user-created genres. MetaX Crack is a great app designed to help you differentiate your movie formats like MP4, M4V, MOV, MKV, WMV, and AVI by getting information from a variety of online sources like IMDB, Amazon, The Movie Database and TheTVDB. MetaX 2.83 Crack + Serial Key Latest Download Free Their second album, Next Future, came out in early 2010, and reached number one on the charts quickly thereafter. In 2009, Girl Next Door had their first chart topper with the single "Infinity," and returned to Kouhaku Uta Gassen. The band also secured a slot on the ultra-popular New Year music TV show Kouhaku Uta Gassen, and scooped the newcomer of the year award for 2008. All of the tracks on the album were used in commercials - a unique achievement for a Japanese artist. and Prague, charted no worse (though the sales were lower), and on Christmas of 2008, Girl Next Door released their first eponymous full-length, which went on to shift 212,000 units. The band debuted with the single "Guzen no Kakuritsu" (2008), hitting number three on the Oricon right off the bat two subsequent singles, supported by videos shot in L.A. Eventually, she caught the eye of Max Matsuura, the label's founder and an über-producer responsible for the stardom of Ayumi Hamasaki, and was granted a sanction to form a band with Daisuke Suzuki, a songwriter and a former keyboard player for Day After Tomorrow. Chisa Maekawa, the vocalist (she goes simply by Chisa) began her show biz career as a dancer, scoring a scholarship to the Avex Artist Academy in 2005. It follows a high school senior who falls in love for the first time. This movie has plenty of twists and turns, so come along for the ride and have some fun.Girl Next Door is a Japanese dance trio that mixes techno/house beats with typical optimistic J-pop melodies. The Girl Next Door is a 2004 American romantic comedy film directed by Luke Greenfield. There is a sweetness to the movie, as it's amazing what a person will do when they fall in love. There are jocks, hot chicks on campus, geeks, and the movie itself has plenty of swearing, bathroom humor, slapstick, you name it. So in the end, this does have a lot of the typical teen flick campiness. They too seem to become more adventurous once Danielle enters the picture, what an influence one person can have. Chris Marquette (Eli) and Paul Dano (Klitz) are funny as Hirsch's dorky friends, and hopefully Marquette will land more roles like this. The other supporting characters are great. He goes from being hilarious to charming to scary in the span of about five minutes and steals almost every scene he's in. I must say, Olyphant is great in this film. She also takes a back seat to the growing tension between the Matthew and the sleazebag Kelly. No insight into her background, how did she get to where she is right now, etc. However, as the film progresses, the movie didn't delve as deeply into Cuthbert's character as it should have. Matthew's once planned out life is now lived more on the edge, and with that, he encounters some interesting characters, such as Kelly, the shady porn director, played flawlessly by Timothy Olyphant. Cuthbert, playing a free-spirited porn star, actually gives a rather understated performance that is sincere and sweet. Straight and narrow, his life is spun on it's head once Danielle (Elisha Cuthbert) enters the picture. Emile Hirsch is great as Matthew Kidman, the ambitious high school senior (who actually looks like he's in high school) with an Ivy League future. However, it would be erroneous to write this film off as a rip-off, it just isn't afraid to show it's influence. The characters (the pimp vs the adult film director) the props (glass egg vs the golden "trophy") as well as the music and language definitely give this film an updated twist on RB. As the title suggest, this movie does have Risky Business written all over it. Though this movie definitely is now part of the illustrious teen film library, it runs a little bit deeper than the average adolescent flick. I must say, the way this movie was marketed, one would figure that this flick is along the lines of such classics as Bring It On and Can't Hardly Wait. I usually wait for teen films to come out on video before viewing them. This type of hay is both softer and sweeter than other hay varieties. But, cereal grain hay does offer a higher percentage of both fiber and protein. Cereal Grain Hay – this style of hay does not produce as much protein as either legume hay or orchard grass-style hay.When consuming alfalfa legume hay varieties a goat can garner roughly 120 percent more energy than they would acquare if eating other types of hay. It also contains 34 percent of crude fiber. Legume hay is comprised of approximately 15 to 22 percent crude protein.
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In 2009, a Chevrolet-branded 1998 Metro we drove as a control subject against the Toyota Prius and Honda Insight needed 2.8 more seconds. During a 12-car mega test in 1992, a Metro made it to 60 mph in 13.1 seconds. And don't yell at your own car for being slow. Can anyone tell me if a 1991 Swift 2 Door Hatchback will fit a 1990 Metro 4 door. The Metro LSi convertible we tested for our January 1991 issue cost an astounding $11,106-that's more than $23,000 in modern dollars-so don't complain about new cars being pricey. There is currently a 1991 Swift that is almost complete and the exact same colour as mine the local PAP so I'm getting what i can from it while i can. We don't need to ask, since we've driven many Metros. Gallant created the treatment plan, including developing a surgery guide, taking bite models, and installing prostheses Winston performed the extraction and implant surgeries.īased on his examination of MacDowell, Gallant confirmed that she needed a full mouth prosthodontic reconstruction, and he developed a course of action that would involve several procedures over a year or more. Gallant and Winston are in different practices, and they each performed different aspects of MacDowell's dental treatment. Mollie Winston, an oral surgeon, for treatment. In February or March 2006, Braswell referred MacDowell to Gallant, a general practitioner with a specialty in prosthetics, and Dr. In February 2006, Braswell examined MacDowell and identified several problems with MacDowell's teeth. She initially sought help from at least two dentists and was referred by one to Dr. Viewed under this standard, the record shows that MacDowell had a series of problems with her teeth. A de novo standard of review applies to an appeal from a grant of summary judgment, and we view the evidence, and all reasonable conclusions and inferences drawn from it, in the light most favorable to the nonmovant. Summary judgment is proper when there is no genuine issue of material fact and the movant is entitled to judgment as a matter of law. Specifically, she challenges the trial court's ruling that MacDowell's consultation with an oral surgeon working with Gallant ended the tolling caused by Gallant's fraudulent concealment of her cause of action. MacDowell argues that the trial court erred by ruling that she filed her action outside of the two-year statute of limitation. Gallant, D.D.S., P.C., in her suit alleging dental malpractice. Ursula MacDowell appeals from the grant of summary judgment to Dr. Accordingly, we conclude that the trial court erred by ruling otherwise. In this case, Winston could not provide a second opinion as to the work that she and Gallant were performing together. The purpose of seeking a second opinion is to overcome the alleged fraud that deters the patient from discovering the true facts. Therefore, by consulting with Winston, MacDowell cannot be deemed to have sought an independent medical opinion such that she reasonably could have discovered her cause of action. Further, as a treating doctor, Winston was not in a position to provide a second opinion as to the procedures that she herself executed as a team with Gallant. Winston was one of MacDowell's original treating physicians and was the very practitioner who allegedly placed the implants incorrectly. We conclude that the trial court erred by ruling that MacDowell's visits to Winston ended the tolling period.Winston again saw MacDowell in January 2008, and discussed her problems. Gallant continued to make several more adjustments over several more office visits in November 2007 through January 2008. Winston told MacDowell that her reconstruction process was taking too long, and after taking some measurements, Winston told MacDowell that her reconstruction was too narrow. Gallant performed several adjustments, and in November 2007, Gallant sent MacDowell to Winston for examination of MacDowell's tongue and mouth due to MacDowell's continued problems. MacDowell complained to Gallant in February 2007 that her tongue overlapped her teeth such that she could not chew without biting her tongue. Ultimately, MacDowell's prosthetics were misaligned and did not perform as desired.
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Let’s Talk ToppingsĪs far as toppings go, the sky’s the limit. A calzone, on the other hand, is pizza dough stuffed with cheese and any other yummy pizza toppings, then folded over like a turnover. A Stromboli is made with square shaped bread dough, topped with sandwich toppings like cold cuts, cheese, and veggies, then rolled into a log and baked. Stromboli vs CalzoneĪ calzone is kind of like an inside-out pizza, while a Stromboli is similar to a rolled up sandwich. In Italy during the 60s most pizza places only delivered calzones because they thought that was the most efficient way to keep the pizza hot during transport. Now, the fillings more resemble popular modern pizza toppings. Traditional calzones were filled with salami, ham or vegetables, mozzarella, ricotta and Parmesan or pecorino cheese, as well as an egg. Now, I don’t know if I would trust my kids to walk around the house with a calzone, but I can see where they are coming from. □ Anyway…calzones have been around since the 18th century! They originated in Naples as a portable, walking-friendly alternative to pizza. So I guess its like a little bread sock full of deliciousness? Maybe I should think of a better way to say that. The word “calzone” actually comes from an Italian word that means “stocking”. A calzone is “a delicate little dough pocket filled with tomato sauce, cheese, and seasoned meat.” It is basically a stuffed pizza or you can think of it as a folded pizza. It’s soft, flavorful, and simple to make! What is a Calzone?īen Wyatt said it best. But if you want to make them more from scratch, try our Homemade Pizza Dough recipe. This easy recipe uses store-bought frozen bread dough, which is so yummy and convenient. We cracked up over this, but then next thing we knew, we were driving to the store to buy ingredients to make calzones. He would call it “The Low-Cal Calzone Zone”. I absolutely love Italian seasoning.I was watching the TV show Parks and Recreation with my family the other night and we watched the episode where Ben Wyatt talks about opening a calzone restaurant. Then top it with egg wash, more parmesan, and Italian seasoning. We stuffed ours with fresh mozzarella, pepperoni, fresh basil and oregano, hot Italian sausage and parmesan. Roll it out, fold it over, and put it on a plate so people can stuff their own. It starts out with my pizza dough recipe, half the dough for each calzone. So, I’ve made my own version to compensate! How to Make Homemade Calzones And they do it well.Īlthough I did have my share of Dough Co., now I don’t live quite so close to campus and I’m not sure my stomach could handle the gargantuan, greasy mass that is a Dough Co. It’s open until 3 a.m.- much later than nearly all places that deliver or serve food period. I may preach that college students aren’t destined to fast food and easy, nasty food, but my biggest weakness in life is pizza.Īll U of O students know about the ultimate late night snack, the only thing open when you’ve been studying all night (or partaking in other activities) and are dying for something greasy and filling: Dough Co. I think I’ve mentioned on here that I love pizza. This post may contain affiliate links which won’t change your price but will share some commission. Complete the look Our model wears a CAMILLA Small and is 510 (178cm) tall. To see how easy it is to collect your order see our video here. An ethereal emerald statement dress for resort wandering, the Into the Mystique Long Sheer Overlay Dress is spellbound with a scene of astrology and the meanings and lessons we take from the universe. 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